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KMID : 1134820070360030291
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Journal of the Korean Society of Food Science and Nutrition
2007 Volume.36 No. 3 p.291 ~ p.297
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Detoxification Effect of Microcluster-Water on Bromobenzene-Induced Liver Damaged Mice
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Park Bum-Ho
Back Kyung-Yern
Lee Sang-Il
Kim Soon-Dong
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Abstract
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This study was conducted to investigate the hepatic detoxification effect of microcluster-water (McW). Animal experiments were divided into 4 groups: distilled water intake group (DC), distilled water intake-bromobenzene treated group (DB), McW intake group (MC), and McW intake-bromobenzene treated group (MB). There were no significant differences in alanine aminotransferase and aspartate aminotransferase activities between DC and MC groups, but the activities in MB group were significantly (p＜0.05) lower than those in DB group. No apparent changes of aniline hydrolase activity were shown in all experimental groups, while glutathione S-transferase activity in MC and MB groups was higher than that in DC and DB, respectively. The content of hepatic lipid peroxide in DC group was similar to that of MC group. In addition, the contents in DB and MB groups were significantly (p＜0.05) increased than that of DC group. The increasing rate in MB group was lower than that of DB group. Also, the electron donating activity of McW was significantly (p＜0.05) higher than that of distilled water. From these results, it could be suggested that McW has the possibility of having detoxification effect of bromobenzene induced hepatic injury by increasing glutathione S-transferase, which is known as a kind of hepatiic detoxification enzyme.
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KEYWORD
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microcluster-water, bromobenzene, liver, alanine aminotransferase, aspartate aminotransferase, glutathione S-transferase
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